Abstract

Objective(s): Apolipoprotein E genotype (APOE) polymorphism affects lipid levels and coronary artery disease (CAD) risk. The aim of this study was to study the association of the Apolipoprotein E genotypes with coronary artery disease in the Iranian population. Materials and Methods: The Apolipoprotein E genotype in DNA samples extracted from 66 CAD+ patients and 61 control subjects by restricting enzyme digestion of amplified exon 4 APOE gene was determined. Results: The ε3 allele was found at similar frequency in control subjects (88.5) and atherosclerosis patients (83.3) (P=0.314). Our results showed that the frequency of the eopen3/eopen3 and ε3/ε4 genotypes increased in three-vessel-disease patients and the frequency of eopen2/eopen2 genotype increased in one-vessel-disease patients. Conclusion: eopen3/eopen3 and eopen3/eopen4 genotypes are suggested to be predisposing factors, which, in combination with environmental factors, may trigger the degree of luminal narrowing. The possible mechanisms remain elusive and require further studies.