(2024) Impact of FCGR2A rs1801274 and IL-6R rs2228145 polymorphisms on tocilizumab response in the Iranian population with severe COVID-19. BMC Infectious Diseases. ISSN 14712334 (ISSN)
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Abstract
Background: Although several genetic biomarkers have been reported in the tocilizumab (TCZ) response in rheumatoid arthritis, no studies have addressed the pharmacogenomics effect of TCZ in COVID-19. Methods: In this prospective longitudinal study, 95 individuals with severe COVID-19 were selected between 2020–2022. The recovery process was measured at 24 h, 48 h, and 10 days before and after taking TCZ. All participants were genotyped using RFLP-PCR. Different genotypes of FCGR2A rs1801274 and IL-6R rs2228145 were compared in terms of the recovery process. Results: 43.2 of patients were male and 56.8 were female with an average age of 58.20(± 16.214) years. The GA genotype for FCGR2A rs1801274 increased the risk of death (OR = 2.83, P = 0.038) and ventilation (OR = 2.71, P = 0.047) in TCZ-treated individuals. However, there was no risk of death and ventilation with IL-6R rs2228145 (P > 0.05). Additionally, docking analysis showed that not only IL6R but also FCGR2A can be a ligand for TCZ. Conclusion: This study provides valuable insights into the impact of genetic variations on the response rate of TCZ in COVID-19 patients. The GA genotype for FCGR2A rs1801274 was associated with poor treatment outcomes. © The Author(s) 2024.
| Item Type: | Article |
|---|---|
| Keywords: | COVID-19 FCGR2A IL-6 receptor Polymorphism Tocilizumab Adult Aged Antibodies, Monoclonal, Humanized COVID-19 Drug Treatment Female Genotype Humans Iran Longitudinal Studies Male Middle Aged Polymorphism, Single Nucleotide Prospective Studies Receptors, IgG Receptors, Interleukin-6 SARS-CoV-2 Treatment Outcome chondroitin sulfate Fc receptor IIa Fc receptor IIa rs1801274 fibronectin glycoprotein immunoglobulin interleukin 6 receptor interleukin 6 receptor rs2228145 lactate dehydrogenase procalcitonin unclassified drug Fc receptor FCGR2A protein, human IL6R protein, human monoclonal antibody Article artificial ventilation breathing rate coronavirus disease 2019 diabetes mellitus distress syndrome DNA extraction gene frequency Horowitz index human hypertension intensive care unit ischemic heart disease longitudinal study molecular docking mortality neutrophil lymphocyte ratio oxygen saturation polyacrylamide gel electrophoresis polymerase chain reaction prospective study restriction fragment length polymorphism single drug dose single nucleotide polymorphism spectrophotometry tachypnea three-dimensional imaging COVID-19 pharmacotherapy genetics Severe acute respiratory syndrome coronavirus 2 virology |
| Journal or Publication Title: | BMC Infectious Diseases |
| Journal Index: | Scopus |
| Volume: | 24 |
| Number: | 1 |
| Identification Number: | https://doi.org/10.1186/s12879-024-10073-0 |
| ISSN: | 14712334 (ISSN) |
| Depositing User: | ms soheila Bazm |
| URI: | http://eprints.ssu.ac.ir/id/eprint/34011 |
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