(2024) The impact of mitochondrial impairments on sperm function and male fertility: a systematic review. Reproductive Biology and Endocrinology. ISSN 14777827 (ISSN)
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Abstract
Background: Besides adenine triphosphate (ATP) production for sustaining motility, the mitochondria of sperm also host other critical cellular functions during germ cell development and fertilization including calcium homeostasis, generation of reactive oxygen species (ROS), apoptosis, and in some cases steroid hormone biosynthesis. Normal mitochondrial membrane potential with optimal mitochondrial performance is essential for sperm motility, capacitation, acrosome reaction, and DNA integrity. Results: Defects in the sperm mitochondrial function can severely harm the fertility potential of males. The role of sperm mitochondria in fertilization and its final fate after fertilization is still controversial. Here, we review the current knowledge on human sperm mitochondria characteristics and their physiological and pathological conditions, paying special attention to improvements in assistant reproductive technology and available treatments to ameliorate male infertility. Conclusion: Although mitochondrial variants associated with male infertility have potential clinical use, research is limited. Further understanding is needed to determine how these characteristics lead to adverse pregnancy outcomes and affect male fertility potential. © The Author(s) 2024.
| Item Type: | Article |
|---|---|
| Keywords: | Assisted reproductive technology In vitro fertilization Male infertility Mitochondria Mitochondrial DNA Mitochondrial membrane potential Pregnancy outcomes Animals Female Fertility Humans Infertility, Male Male Reactive Oxygen Species Sperm Motility Spermatozoa adenosine triphosphate antioxidant calcium cell nucleus DNA reactive oxygen metabolite steroid hormone acrosome reaction aging apoptosis calcium homeostasis cell maturation disorders of mitochondrial functions extrachromosomal inheritance fertilization gene dosage genetic variation germ cell human infertility therapy intracytoplasmic sperm injection lifestyle modification male fertility mitochondrial genome obesity oxidative stress oxygen consumption pregnancy outcome Review semen cryopreservation sperm capacitation sperm function spermatozoon motility steroidogenesis systematic review animal metabolism mitochondrion pathophysiology physiology spermatozoon |
| Journal or Publication Title: | Reproductive Biology and Endocrinology |
| Journal Index: | Scopus |
| Volume: | 22 |
| Number: | 1 |
| Identification Number: | https://doi.org/10.1186/s12958-024-01252-4 |
| ISSN: | 14777827 (ISSN) |
| Depositing User: | ms soheila Bazm |
| URI: | http://eprints.ssu.ac.ir/id/eprint/34004 |
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