Abstract

Introduction: The liver is very vulnerable because it is one of the main detoxification organs in the body.In this study, the effect of henna on liver enzymes and lipid profile in rats exposed to lipopolysaccharide (LPS) was assessed. Methods and Materials: In the present study, 28 male mice were divided into 4 groups: 1-sham: (Tween 1); 2-Tween 1 + LPS (1 mg/kg); 3&4-henna leaf Extract (300 and 500 mg/kg) along with LPS injection. On the seventh day, the animals were anesthetized and a serum sample was isolated to assess liver enzymes and lipid profiles. Results: LPS increased liver enzymes and decreased lipid profile including serum cholesterol, triglyceride, and HDL levels. Henna leaf extract was able to reduce the changes caused by LPS. Conclusions: The results of this study showed that LPS increases SGOT and SGPT. Many studies have shown an increase in liver enzymes during liver inflammation. Also, studies have shown that during the acute phase of liver inflammation, the amount of lipid profile decreases, which was similar to the results of the present study. In examining the effect of henna on the changes caused by LPS, it was observed that henna improves the level of liver enzymes and lipid profile. Henna with the scientific name Lawsonia inermis belongs to the Lythraceae family. This plant contains more than a hundred types of useful biological substances, including flavonoids and phenolic glycosides and its antioxidant and anti-inflammatory role is well known. In brief, in the present study, henna leaf extract could reduce the changes caused by LPS on serum liver enzymes and lipid profiles. © 2023, Semnan University of Medical Sciences. All rights reserved.