Abstract

To determine the effect of curcumin and menthol biological active compounds local rabbits cutaneous skin wounds by second intention, forty rats by average age, 8 months and average weight of 2.0 +/- 250 kg were selected to evaluate cutaneous wound healing after treatment with different levels of curcumin and menthol. Experimental wound excision model in rabbits was created by means of a skin punch of 2 cm diameter. The rabbits were topically treated for seventeen days with a saline control or decoctions of mixed with common thistle and thyme derived extracts with carboxymethyl cellulose. The centripetal retraction, clinical, and histological aspects of the wounds were observed until complete healing. The phototherapeutics agent presents in curcumin improved cicatrization of cutaneous lesions in rabbits' skin during the first days of treatment. The treatments were beneficial to the reparation process of wound healing. The phytotherapeutics agent present in menthol showed positive effects in the inflammatory phase and on the reparation process. The use of menthol at 200 mg showed a positive effect on the macroscopic aspect of cutaneous lesions in rabbits only during the first treatment days. In conclusion different levels of curcumin and menthol improved fibroplasia and its pytotherapeutic activity may be useful in topical treatment of cutaneous lesions in local rabbits.