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Repository of Research and Investigative Information

Shahid Sadoughi University of Medical Sciences

Interactions between vitamin D binding protein variants and major dietary patterns on mental health status in apparently healthy adults

(2024) Interactions between vitamin D binding protein variants and major dietary patterns on mental health status in apparently healthy adults. European Journal of Integrative Medicine. p. 8. ISSN 1876-3820

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Abstract

Introduction: Recent studies have shown that the risks of mental disorders resulting from vitamin D deficiency, such as depression, anxiety and stress, can be affected by various high-risk alleles. Among the genes interacting with environmental factors are those associated with vitamin D binding protein (DBP) that affects the status of 25- OH vitamin D. Therefore, the present study aimed to determine the interaction between dietary patterns and DBP gene variants on mental health status in adults. Methods: This cross-sectional study was conducted on a random sample of adult participants (n = 265 and 18-55 years old) in Tehran. Major dietary patterns were determined using principal component analysis (PCA) method on 24 food groups, using a valid and reliable 147-item food frequency questionnaire (FFQ). DBP genotypes were determined by polymerase chain reactions - restriction fragment length polymorphism (PCR-RFLP). Data about the mental health status were collected using the Depression, Anxiety, Stress Score (DASS-21). Results: Results demonstrated strong interactions between higher adherence to healthy dietary patterns in individuals with the major allele (low-risk allele) carriers of rs7041 (GG genotype), in relation to reduced stress score (OR= -2.54, 95 CI = -4.60 to -0.48, P interaction = 0.02). Also, individuals with higher adherence to healthy dietary patterns with GG genotype of rs7041 indicated reduced stress score, but it was not significant (OR = -1.84, 95 CI = 0.18 to -3.86, P interaction = 0.07). Conclusion: The present evidence indicates that interactions between healthy dietary patterns with DBP variants (rs7041 - GG genotype) may effectively reduce the odds of mental disorders , especially in stress, through consuming healthy food groups and inherited low-risk alleles.

Item Type: Article
Keywords: Interaction Vitamin D binding protein gene Dietary pattern Depression Anxiety Stress physical-activity questionnaire psychiatric-disorders plasma-concentrations atherosclerosis risk 25-hydroxyvitamin d gene polymorphisms relative validity depression anxiety association Integrative & Complementary Medicine
Page Range: p. 8
Journal or Publication Title: European Journal of Integrative Medicine
Journal Index: WoS
Volume: 67
Identification Number: https://doi.org/10.1016/j.eujim.2024.102352
ISSN: 1876-3820
Depositing User: ms soheila Bazm
URI: http://eprints.ssu.ac.ir/id/eprint/33174

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