(2012) Aloe vera leaf gel in treatment of advanced type 2 diabetes mellitus needing insulin therapy: A randomized double-blind placebo-controlled clinical trial. Journal of Medicinal Plants. pp. 19-27. ISSN 2717204X (ISSN)
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Abstract
Background: Advanced type 2 diabetes mellitus (T2DM) needing insulin therapy is a common disease. Previous studies indicate that aloe (Aloe vera L.) leaf gel may positively affect the blood glucose and lipid levels in patients with advanced T2DM needing insulin. Objective: Evaluation of the efficacy and safety of aloe leaf gel in the treatment of type 2 diabetic patients resistant to oral synthetic anti-hyperglycemic drugs needing insulin. Methods: In this randomized double - blind placebo-controlled clinical trial with the patients aged 40-60 years, the efficacy and safety of taking aloe leaf gel (one 300 mg capsule every 12 hours for 2 months) combined with oral synthetic anti-hyperglycemic drugs in treatment of 35 patients were evaluated and compared with the placebo group (n = 35). Results: The aloe leaf gel lowered the blood levels of fasting glucose and glycosylated hemoglobin significantly (p = 0.041 and p = 0.023 respectively) without any significant effects on the lipid profile and liver/kidney function tests (p > 0.05) compared with placebo at the endpoint. No adverse effects were reported. Conclusion: The results suggest that aloe leaf gel may safely improve glycemic control in patients with advanced T2DM needing insulin.
| Item Type: | Article |
|---|---|
| Keywords: | Aloe vera Glycemic control Patient Type 2 diabetes Aloe alanine aminotransferase alkaline phosphatase Aloe vera extract aspartate aminotransferase creatinine gamma glutamyltransferase glucose glycosylated hemoglobin hemoglobin A1c high density lipoprotein low density lipoprotein oral antidiabetic agent very low density lipoprotein absence of side effects adult article capsule endoscope cholesterol blood level controlled study creatinine blood level diabetic patient disease severity double blind procedure drug efficacy drug safety female gamma glutamyl transferase blood level glucose blood level human insulin treatment kidney function test liver function test major clinical study male non insulin dependent diabetes mellitus randomized controlled trial urea nitrogen blood level |
| Page Range: | pp. 19-27 |
| Journal or Publication Title: | Journal of Medicinal Plants |
| Volume: | 11 |
| Number: | 43 |
| ISSN: | 2717204X (ISSN) |
| Depositing User: | Mr mahdi sharifi |
| URI: | http://eprints.ssu.ac.ir/id/eprint/32569 |
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