Abstract

Radiotherapy consisting of external beam radiotherapy (EBRT) and internal radioisotope therapy (RIT) has a wide application for treating cancer as clinical trials. This study provides some conditions to prove that tungsten oxide nanoparticles (WO3) is a radio sensitizer.The peripheral blood mononuclear cells (PBMCs) were used to calculate inhibitory concentration (IC).The AGS cell line exposed the concentration of 89.6 μg/mL (IC20) WO3 nanoparticles that was optimal and its radio sensitization was examined in megavoltage photons radiation of 6 MV x-rays. The sensitivity enhancement ratio (SER) and dose enhancement factor (DEF) was determined 1.24 and 1.68 respectively. We described the mechanisms of creating WO3 nanoparticles toxicity and genotoxicity in different concentrations on AGS cell line. The mean size of WO3 NPs by transmission electron microscopy was measured 31.89±3.82 nm. Tungsten oxide Nanoparticles cause to reduce cell viability, remove membrane and damage to DNA. There was a meaningful increasing in damages to DNA and proliferation cell potency and also significantly reducing cell viability in concentrations more than 100 μg/mL. © 2019, University of Kashan.