(2019) FOXP3 genetic variation at position -2383 C/T (rs3761549) in patients with breast cancer. Middle East Journal of Cancer. pp. 299-304. ISSN 20086709 (ISSN)
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Abstract
Background:We investigated the possibility of an association between the C-2383T polymorphism (rs3761549) in the promoter region of the FOXP3 gene with breast cancer. Methods: The study groups consisted of 250 women diagnosed with breast cancer (case group) and 250 healthy women (control group). Polymerase chain reactionrestriction fragment length polymorphism was performed for genotyping. Results: Breast cancer cases had a C allele frequency of 455 (91) and T allele frequency of 45 (9). The control group had a C allele frequency of 468 (93.6) and 32 (6.4) for the T allele. The CC genotype was present in 206 (82.4) patients, 43 (17.2) patients had the CT genotype, and the TT genotype was observed in 1 (0.4) patient. In the control group, 219 (87.6) had the CC genotype, whereas 30 (12) had the CT genotype, and 1 (0.4) had the TT genotype. Statistical analysis revealed no significant differences in the distribution of alleles and genotypes between patients and controls (P>0.05). There was no significant association between genotype distribution and patients’ clinicopathological factors. Conclusion: Our results do not support an association between the FOXP3 -2383 C/T polymorphism and breast cancer in a population from southern Iran. © 2019, Shiraz University of Medical Sciences. All rights reserved.
| Item Type: | Article |
|---|---|
| Keywords: | Breast cancer FOXP<sup>3</sup> gene PCR-RFLP Single nucleotide polymorphism transcription factor FOXP3 adult agar gel electrophoresis Article cancer grading cancer patient cancer staging case control study controlled study distant metastasis DNA extraction DNA polymorphism female gene frequency genetic variation genotype genotyping technique histopathology human human tissue major clinical study polymerase chain reaction promoter region restriction fragment length polymorphism transillumination tumor necrosis tumor volume |
| Page Range: | pp. 299-304 |
| Journal or Publication Title: | Middle East Journal of Cancer |
| Volume: | 10 |
| Number: | 4 |
| Identification Number: | https://doi.org/10.30476/mejc.2019.78638 |
| ISSN: | 20086709 (ISSN) |
| Depositing User: | Mr mahdi sharifi |
| URI: | http://eprints.ssu.ac.ir/id/eprint/31896 |
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