(2020) The interplay between EBV and KSHV viral products and NF-κB pathway in oncogenesis. Infectious Agents and Cancer. ISSN 17509378 (ISSN)
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Abstract
Among the DNA tumor viruses Epstein-Barr virus (EBV) and Kaposi sarcoma herpesvirus (KSHV), account for a considerable percentage of virus-associated cancers. Deregulation of transcription factors signaling pathways is one of the most significant oncogenic characteristics of EBV and KSHV. NF-κB is a transcription factor that play a remarkable role in oncogenesis because of its function as a master regulator of a spectrum of genes involved in physiological and pathophysiological process. Constitutive activation of NF-κB is a frequent and well-described event in many human malignancies. Compelling evidence represent EBV and KSHV are capable of targeting different components of NF-κB cascade. Here, we summarized recent findings to clarify the precise relationship between dysregulation of NF-κB and EBV and KSHV-related malignancies. This essay also emphasizes on contribution of various viral products in developing cancer through alteration of NF-κB signaling pathway. © 2020, The Author(s).
| Item Type: | Article |
|---|---|
| Keywords: | EBV KSHV Neoplasm NF-κB B cell activating factor receptor B lymphocyte receptor CD40 antigen cyclooxygenase 2 Epstein Barr virus antigen 1 glucose transporter 1 I kappa B kinase alpha I kappa B kinase beta immunoglobulin enhancer binding protein intercellular adhesion molecule 1 interleukin 1 interleukin 8 latent membrane protein 1 latent membrane protein 2 latent membrane protein 2A lymphotoxin beta receptor mammalian target of rapamycin complex 1 microRNA 146a pattern recognition receptor phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase protein bcl 2 receptor activator of nuclear factor kappa B transcription factor RelA transforming growth factor beta transforming growth factor beta activated kinase 1 tumor necrosis factor tumor necrosis factor receptor tumor necrosis factor receptor superfamily member 6 unclassified drug vasculotropin 3' untranslated region apoptosis carboxy terminal sequence carcinogenesis cytokine response enzyme activation enzyme inhibition enzyme phosphorylation Epstein Barr virus human Human herpesvirus 8 malignant neoplasm nonhuman pathophysiology pleiotropy priority journal protein degradation protein expression protein targeting Review signal transduction ubiquitination upregulation |
| Journal or Publication Title: | Infectious Agents and Cancer |
| Volume: | 15 |
| Number: | 1 |
| Identification Number: | https://doi.org/10.1186/s13027-020-00317-4 |
| ISSN: | 17509378 (ISSN) |
| Depositing User: | Mr mahdi sharifi |
| URI: | http://eprints.ssu.ac.ir/id/eprint/31739 |
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