(2020) Association of catechol-O-methyltranferase 472G>A (Val158Met) polymorphism with susceptibility to fibromyalgia syndrome. Journal of Orthopaedics. pp. 257-260. ISSN 0972-978X (Print) 0972-978X (Electronic) 0972-978X (Linking)
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Abstract
BACKGROUND: Several lines of research have suggested that the 472G > A (Val158Met) polymorphism at Catechol-O-methyltranferase (COMT) gene is implicated in the pathophysiology of FMS. Here, we have evaluated the association of COMT 472G > A polymorphism with risk of FMS. METHODS: In this study 250 patients with FMS and 250 healthy controls were evaluated for COMT 472G > A polymorphism by RFLP-PCR assay. RESULTS: There were no significant differences in the allele and genotype frequencies of COMT 472G > A polymorphism between FMS cases and healthy controls. CONCLUSIONS: Our results suggested that the COMT 472G > A polymorphism may not be risk factor for development of FMS.
| Item Type: | Article |
|---|---|
| Keywords: | Catechol-O-Methyltransferase Fibromyalgia Pain Polymorphism |
| Page Range: | pp. 257-260 |
| Journal or Publication Title: | Journal of Orthopaedics |
| Volume: | 20 |
| Identification Number: | https://doi.org/10.1016/j.jor.2020.01.013 |
| ISSN: | 0972-978X (Print) 0972-978X (Electronic) 0972-978X (Linking) |
| Depositing User: | Mr mahdi sharifi |
| URI: | http://eprints.ssu.ac.ir/id/eprint/31058 |
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