(2022) Association of+1923C > T,-1112C > T and+2044A > G Polymorphisms in IL-13 Gene with Susceptibility to Pediatric Asthma: A Systematic Review and Meta-Analysis. Fetal and Pediatric Pathology. pp. 259-277. ISSN 1551-3815
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Abstract
Background:Previous studies have provided conflicting evidence implicating the IL-13 polymorphism and pediatric asthma. Thus, we performed a meta-analysis to combine and analyze the available studies to provide more accurate conclusions.Methods:A comprehensive retrieval in PubMed, EMBASE, Web of Science, and CNKI was performed up to February 05, 2020.Results:A total of 39 case-control studies including 15 studies with 4,968 cases and 7,091 controls were on +1923 C > T, ten studies with 3,175 cases and 2,983 controls on -1112 C > T, and 14 studies with 4,476 cases and 5,121 controls on +2044 A > G were selected. Pooled data showed that the IL-13 + 1923 C > T, -1112 C > T and +2044 A > G polymorphisms were significantly associated with risk of pediatric asthma. The IL-13 + 1923 C > T (Asians and Africans), -1112 C > T (Caucasians) and +2044 A > G (Asians) polymorphisms were more frequently associated in these ethnic groups.Conclusions:Our pooled data indicated that IL-13 + 1923 C > T, -1112 C > T and +2044 A > G polymorphisms were correlated with risk of pediatric asthma.
| Item Type: | Article |
|---|---|
| Keywords: | Asthma pediatric interleukin 13 polymorphism meta-analysis single-nucleotide polymorphisms korean children tobacco-smoke risk-factors interleukin-13 atopy ige impact Pathology Pediatrics |
| Page Range: | pp. 259-277 |
| Journal or Publication Title: | Fetal and Pediatric Pathology |
| Journal Index: | WoS |
| Volume: | 41 |
| Number: | 2 |
| Identification Number: | https://doi.org/10.1080/15513815.2020.1783406 |
| ISSN: | 1551-3815 |
| Depositing User: | Mr mahdi sharifi |
| URI: | http://eprints.ssu.ac.ir/id/eprint/30054 |
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