(2023) Liposomal nanocarriers containing siRNA as small molecule-based drugs to overcome cancer drug resistance. Nanomedicine. p. 24. ISSN 1743-5889
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Abstract
This review discusses the application of nanoliposomes containing siRNA/drug to overcome multidrug resistance for all types of cancer treatments. As drug resistance-associated factors are overexpressed in many cancer cell types, pumping chemotherapy drugs out of the cytoplasm leads to an inadequate therapeutic response. The siRNA/drug-loaded nanoliposomes are a promising approach to treating multidrug-resistant cancer, as they can effectively transmit a small-molecule drug into the target cytoplasm, ensuring that the drug binds efficiently. Moreover, nanoliposome-based therapeutics with advances in nanotechnology can effectively deliver siRNA to cancer cells. Overall, nanoliposomes have the potential to effectively deliver siRNA and small-molecule drugs in a targeted manner and are thus a promising tool for the treatment of cancer and other diseases. GRAPHICS .
| Item Type: | Article |
|---|---|
| Keywords: | cancer codelivery liposomal nanocarriers MDR siRNA drugs small interfering rna pegylated hyaluronic-acid factor-kappa-b co-delivery breast-cancer multidrug-resistance cationic liposomes p-glycoprotein tumor penetration lung-cancer Biotechnology & Applied Microbiology Science & Technology - Other Topics |
| Page Range: | p. 24 |
| Journal or Publication Title: | Nanomedicine |
| Journal Index: | WoS |
| Identification Number: | https://doi.org/10.2217/nnm-2023-0176 |
| ISSN: | 1743-5889 |
| Depositing User: | Mr mahdi sharifi |
| URI: | http://eprints.ssu.ac.ir/id/eprint/29005 |
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