Abstract

BACKGROUND/AIMS This study was conducted to investigate survival and its associated factors in patients with clear cell renal cell carcinoma (CCRCC). MATERIAL and METHODS This retrospective study recruited patients diagnosed with CCRCC in Shahid Rahnemoon Hospital, Yazd, Iran, followed them up from their presentation until their death or end of the study and examined their demographic information and clinical and tumor characteristics. Continuous variables were expressed as mean +/- SD, and univariate analyses of survival were conducted using the Kaplan-Meier method and log-rank test and multivariate analyses using the Cox regression model. RESULTS The study recruited 206 patients, including 132 males, with CCRCC and a mean age of 57.9 +/- 13.6 years. During the follow up, 53.9 (n = 111) of the patients survived and data regarding the survival status of 24.3 (n = 50) patients were missing. The mean survival duration was obtained as 59.9 +/- 2.7 months. The independent survival indicators were grade 4 (HR: 2.4, 95 CI: 0.4-5.7, P = .02), older age (HR: 4.14, 95 CI: 1.7-8.4, P = .02), and treatment method includes post-operative chemotherapy (HR: 4.9, 95 CI: 1.7-10.8, P = .004) and postoperative radiochemotherapy (HR: 8.4, 95 CI: 1.9-16.2, P = .03). CONCLUSION This study found survival to be negatively correlated with grade 4, older age, and treatment method, i.e. post-operative chemotherapy and post-operative radiochemotherapy.