Abstract

BACKGROUND Coronary artery disease (CAD) is a major cause of mortality and morbidity with high health care cost in both developed and developing countries. CAD accounts for nearly 50% of all yearly deaths in Iran. OBJECTIVE The aim of this study is to explore the main CAD risk factors in the urban areas of Yazd in the Islamic Republic of Iran. METHODS A hospital-based case-control study was conducted to investigate the role of the important CAD risk factors in urban area of Yazd city from December 2007 to June 2008. A total of 436 subjects in the age group of 30 to 75 years (218 cases and 218 controls) were included in this study. The tools of enquiry were a pretested and precoded questionnaire, physical examination, and laboratory findings. A confidence level of 95% and study power of 80% were considered for the interpretation of possible significant findings. Gender-wise stratified analysis was separately done for men and women using multiple conditional logistic regression. RESULTS A total of 75.5% of the participants were men and 24.5% were women. Five variables, including unskilled jobs, physical inactivity, giving positive history of hypertension, high levels of waist/hip ratio, and low levels of high-density lipoprotein (HDL) were the factors that could account for significant predictors of CAD in males on the logistic model (P < .05). No such significant CAD predictors were found for women. CONCLUSION The findings showed that categories of nonprofessional, physical inactivity, positive history of hypertension, wais/hip ratio ≥0.9 and HDL levels ≤40 mg/dL are the significant risk factors that can predict CAD in male residents of Yazd.