(2022) Progress toward molecular therapy for diabetes mellitus: A focus on targeting inflammatory factors. Diabetes Research and Clinical Practice.
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Abstract
Diabetes mellitus (DM) has been the most prevalent global metabolic disease, turning into a serious risk for human health. Several researches have recorded a role for inflammation and immunity in the pathogenesis of both in T1DM and in T2DM. Lots of chemical agents are available to control and to cure diabetic patients, which are not always sufficient for euglycemia maintenance and late stage diabetic complications avoidance. Therefore, newborn therapeutic methods to refine clinical outcomes in DM are required. Nucleic-acid-based therapy also known as gene expression level regulator within the target cells has been calculated to be promising in various diseases. Thus, pronounced attempts have been dedicated to develop new targeted molecular therapy aimed at improving insulin resistance in DM. This review mainly focuses on recent progress in DM molecular therapy and whether, has potential efficacy against inflammatory mediators involved in DM. © 2022 Elsevier B.V.
| Item Type: | Article |
|---|---|
| Keywords: | adiponectin; fatty acid binding protein 4; fibroblast growth factor 21; phosphatidylinositol 3 kinase; untranslated RNA; vasoactive intestinal polypeptide; virus vector, clinical feature; clustered regularly interspaced short palindromic repeat; diabetes mellitus; exosome; human; molecular therapy; nonhuman; phenotype; protein expression; Review; risk factor; signal transduction; viral gene therapy; complication; genetics; inflammation; insulin dependent diabetes mellitus; insulin resistance; newborn; non insulin dependent diabetes mellitus, Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Humans; Infant, Newborn; Inflammation; Insulin Resistance |
| Journal or Publication Title: | Diabetes Research and Clinical Practice |
| Volume: | 189 |
| Publisher: | Elsevier Ireland Ltd |
| Depositing User: | ms soheila Bazm |
| URI: | http://eprints.ssu.ac.ir/id/eprint/12432 |
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