(2021) Leishmanial apolipoprotein A-I expression: A possible strategy used by the parasite to evade the host's immune response. Future Microbiology. pp. 607-613.
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Abstract
Apolipoprotein A-I (apo A-I) represents the main component of the Trypanosome lytic factor (TLF) which contributes to the host innate immunity against Trypanosoma and Leishmania. These parasites use complex and multiple strategies such as molecular mimicry to evade or subvert the host immune system. Previous studies have highlighted the adaptation mechanisms of TLF-resistant Trypanosoma species. These data might support the hypothesis that Leishmania parasites (amastigote forms in macrophages) might express apo A-I to bypass and escape from TLF action as a component of the host innate immune responses. The anti-inflammatory property of apo A-I is another mechanism that supports our idea that apo A-I may play a role in Leishmania parasites allowing them to bypass the host innate immune system. © 2021 Future Medicine Ltd.. All rights reserved.
| Item Type: | Article |
|---|---|
| Keywords: | apolipoprotein A1; high density lipoprotein; Trypanosome lytic factor; unclassified drug, amastigote; antiinflammatory activity; Article; host cell; host parasite interaction; immune response; immunomodulation; innate immunity; Kinetoplastida; Leishmania; macrophage; molecular mimicry; nonhuman; priority journal; protein expression; visceral leishmaniasis |
| Page Range: | pp. 607-613 |
| Journal or Publication Title: | Future Microbiology |
| Volume: | 16 |
| Number: | 8 |
| Depositing User: | ms soheila Bazm |
| URI: | http://eprints.ssu.ac.ir/id/eprint/11862 |
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