Repository of Research and Investigative Information

Repository of Research and Investigative Information

Shahid Sadoughi University of Medical Sciences

Preimplantation factor (PIF): A peptide with various functions

(2020) Preimplantation factor (PIF): A peptide with various functions. Jornal Brasileiro de Reproducao Assistida. pp. 214-218.

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Abstract Preimplantation Factor (PIF) is a novel fifteen amino acid linear peptide (MVRIKPGSANKPSDD), which has different biological functions in mammalian species e.g. its role in neuron restoration, pregnancy and related disorders, and also in autoimmune diseases. Since all clinical studies have shown that PIF has both local and systemic effects, it can be considered as an integrated therapy for the treatment of inflammation conditions, along with the prevention of advanced disease. The synthetic PIF (sPIF) analog is a good representative of native PIF action, and it regulates peripheral immune cells to achieve endurance without immune suppression - an effective agent in nonpregnant autoimmune models. This study provides information, from evidence-based studies so far about PIF's different functional aspects.

Item Type: Article
Page Range: pp. 214-218
Journal or Publication Title: Jornal Brasileiro de Reproducao Assistida
Volume: 24
Number: 2
Depositing User: ms soheila Bazm
URI: http://eprints.ssu.ac.ir/id/eprint/11553

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