Abstract

ABSTRACTAim:Although antidepressants can relieve the symptoms of depression in patients with type-2 diabetes mellitus,the effect of vitamin D supplementation as an antidepressant remains unclear. The present study aimed toinvestigate the impact of intramuscular vitamin D supplement injections on depression and anthropometricindices in patients with type 2 diabetes who had vitamin D deficiency.Methods:In this randomized controlled clinical trial, 50 patients with type 2 diabetes mellitus who had vitaminDdeficiency were randomly divided into two groups of 25 participants. The experimental group received200,000 IU of vitamin D injection at week 0 and week 4 of the study. Anthropometric indices, serum 25-hydroxyvitamin D [25(OH)D] concentrations and Beck depression test were evaluated at the beginning and after8 weeks.Results:There were no significant differences in the baseline measures of 25(OH)D concentrations between theexperimental and the non-experimental groups (P = 0.78). No significant correlation was observed between thedepression score and serum 25(OH)D concentrations (r = -0.008, P = 0.95). After two months, serum 25(OH)Dconcentrations significantly increased in the experimental group compared with the non-experimental group(p < 0.001). The mean measures of weight, fat level, waist to hip circumference ratio and the mean depressionscore were not significant in the two groups after the intervention.Conclusions:The intramuscular vitamin D supplement injections increased serum 25(OH)D concentrations inpatients with type 2 diabetes mellitus who had vitamin D deficiency, while it had no significant effect on thedepression status. (http://www.irct.ir:IRCT20171003036539N2)