(2017) Facile synthesis and antiproliferative activity of 7H-benzo7,8chromeno2,3-dpyrimidin-8-amines. European Journal of Medicinal Chemistry. pp. 128-136.
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Abstract
A series of 7H-benzo7,8chromeno2,3-dpyrimidin-8-amines 6a-t were synthesized as new potential antiproliferative agents. The in vitro antiproliferative activity evaluation of title compounds using MTT assay revealed that most compounds showed significant activity against tested cancer cell lines (A549, MOLT-4, and HeLa). The 2-fluoro-aniline derivatives 6e and 6l were the most active compounds against A549 and MOLT-4 cells, respectively. The benzylamine analog 6h showed superior activity against HeLa cells. However, compound 6l with IC50 values of 5.2�6.9 μM had the best profile of activity against all tested cell lines. The morphological and flow cytometric analyses showed that compound 6l can induce apoptosis in the MOLT-4 cells. © 2016 Elsevier Masson SAS
| Item Type: | Article |
|---|---|
| Keywords: | antineoplastic agent; pyrimidine derivative, cell proliferation; cell survival; chemistry; drug design; drug effects; drug screening; human; synthesis; tumor cell line, Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chemistry Techniques, Synthetic; Drug Design; Drug Screening Assays, Antitumor; Humans; Pyrimidines |
| Page Range: | pp. 128-136 |
| Journal or Publication Title: | European Journal of Medicinal Chemistry |
| Volume: | 127 |
| Publisher: | Elsevier Masson SAS |
| Depositing User: | ms soheila Bazm |
| URI: | http://eprints.ssu.ac.ir/id/eprint/10038 |
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