Abstract

Objective This study screens the miR-499 differences in off-pump CABG and evaluates the relationship of miR-499 with heart ejection fraction and uric acid (UA) levels. Methods and results 70 candidates undergoing CABG were selected and left ventricular EF, blood samples and hemodynamic data were taken at different time points. Statistically significant correlation was found between circulating levels of cardiac troponin I (cTnI), UA and miR-499, after off-pump CABG (p < 0.001). Furthermore, post-operative EF was strongly affected by pre-operative miR-499 expression levels vs. UA (p < 0.005). Conclusion Pressure overload and ischemia result in oxidative stress (OS) on the cardiovascular system. The elevated levels of miR-499 expression in ischemic myocardium protect it from OS, while declining protective effects were observed in decreased levels of miR-499 in UA concentrations. © 2016 The Czech Society of Cardiology