(2015) Synthesis and Evaluation of Coumarin-Resveratrol Hybrids as 15-Lipoxygenaze Inhibitors. Synthetic Communications. pp. 751-759.
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Abstract
A series of coumarin-resveratrol hybrids, 3-arylcoumarin derivatives 3a-u, were synthesized through the intermolecular condensation reaction of various salicylaldehydes and phenylacetic acids in the presence of 1,4-diazabicyclo2.2.2octane under solvent-free conditions. All the synthesized compounds were screened for their inhibitory potency against soybean 15-lipoxygenase. Among them, three compounds (3c, 3j, and 3q) showed good enzyme-inhibitory activities. GRAPHICAL ABSTRACT. Copyright © 2015 Taylor & Francis Group, LLC.
| Item Type: | Article |
|---|---|
| Keywords: | 1,4 diazabicyclo2.2.2octane; arachidonate 15 lipoxygenase; coumarin derivative; cyclooctane derivative; lipoxygenase inhibitor; phenylacetic acid derivative; quercetin; resveratrol; salicylaldehyde, Article; controlled study; cyclization; drug potency; drug screening; drug synthesis; enzyme inhibition; polymerization; reaction time; soybean |
| Page Range: | pp. 751-759 |
| Journal or Publication Title: | Synthetic Communications |
| Volume: | 45 |
| Number: | 6 |
| Publisher: | Taylor and Francis Inc. |
| Depositing User: | ms soheila Bazm |
| URI: | http://eprints.ssu.ac.ir/id/eprint/9501 |
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