Repository of Research and Investigative Information

Repository of Research and Investigative Information

Shahid Sadoughi University of Medical Sciences

Toxic effects of Mn2O3 nanoparticles on rat testis and sex hormone.

(2015) Toxic effects of Mn2O3 nanoparticles on rat testis and sex hormone. Journal of natural science, biology, and medicine. pp. 335-9. ISSN 0976-9668

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Abstract

BACKGROUND AND OBJECTIVE The safety of Mn2O3 nanoparticles (which are extensively used in industries) on male reproductive system is not known. Hence, we investigated the effects of Mn2O3 nanoparticles on male reproductive system. MATERIALS AND METHODS A total of 40 Wistar adult male rats were randomly assigned to four groups of 10 rats each. Three groups received Mn2O3 solution in concentrations of 100, 200, and 400 ppm orally for 14 days; the control group received equal volume of saline solution. Blood samples and testicles were collected for analysis. RESULTS Significant reduction in luteinizing hormone (LH), follicle-stimulating hormone (FSH), testosterone, spermatogonial cells, primary spermatocyte, spermatid and Leydig cell was observed in the Mn2O3 nanoparticles treated groups compared with controls. CONCLUSION Mn2O3 nanoparticles significantly reduce FSH, LH, and testosterone levels resulting in a significant reduction in testicular cytology.

Item Type: Article
Page Range: pp. 335-9
Journal or Publication Title: Journal of natural science, biology, and medicine
Volume: 6
Number: 2
ISSN: 0976-9668
Depositing User: ms soheila Bazm
URI: http://eprints.ssu.ac.ir/id/eprint/9476

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