Abstract

Background: Vitamin D supplementation during pregnancy has been supposed to defend against adverse gestational outcomes. Objective: This randomized clinical trial study was conducted to assess the effects of 50,000 IU of vitamin Devery two weeks supplementation on the incidence of gestational diabetes (GDM), gestational hypertension, preeclampsia and preterm labor, vitamin D status at term and neonatal outcomes contrasted with pregnant women that received 400 IU vitamin D daily. Materials and Methods:500 women with gestational age 12-16 weeks and serum 25 hydroxy vitamin D (25 (OH) D)less than 30 ng/ml randomly categorized in two groups. Group A received 400 IU vitamin D daily and group B 50,000 IU vitamin Devery 2 weeks orally until delivery. Maternal and Neonatal outcomes were assessed in two groups. Results: The incidence of GDM in group B was significantly lower than group A(6.7 versus 13.4) and oddsratio (95 Confidence interval) was 0.46 (0.24-0.87) (P=0.01). The mean ± SD level of 25(OH)D at the time of delivery in mothers in group B was significantly higher than A (37.9 ± 19.8 versus 27.2 ±1 8.8 ng/ml, respectively) (P=0.001).There were no differences in the incidence of preeclampsia, gestational hypertension, preterm labor, and low birth weight between two groups. The mean level of 25(OH)D in cord blood of group B was significantly higher than group A (37.9±18versus 29.7±19ng/ml, respectively). Anthropometric measures between neonates were not significantly different. Conclusion: Our study showed 50,000 IU vitamin D every 2 weeks decreased the incidence of GDM. © 2016, Research and Clinical Center for Infertitlity. All rights reserved.