Abstract

Introduction: Cervical cancer is the third most gynecological cancer and one of the common causes of cancer death in women in Iran and the other developing countries. Human Papilloma Virus (HPV) is a known Risk factor in cervical cancer, but according to HPV deference types, the high risk and low risks differ. Material and method: We evaluate the most common high risk and low risk HPV type in 180 females with an atypical squamous cells of undetermined significance (ASCUS) results in pap smear in Gynecological Oncology Clinic in Shahid Sadoughi Hospital in Yazd, Iran within 2012 to 2014.HPV typing was done with polymerase chain reaction (PCR) method. The data obtained were recorded in a questionnaire and analyzed by SPSS software. Result: More common low risk HPV type in ASCUS patients was type 6 (63.6) and then type 11 (36.4). Type 16 was the most common high risk HPV type Discussion: HPV DNA typing for better management of women With ASCUS is important and this study showed HPV type 16 is the most prevalent type in ASCUS patients. It seems the living region is important in HPV type distribution and Quadri-valant Vaccine can prevent cervical cancer in Iran because the most common low risk HPV is type6 and 11, and HPV 16 is the most common high risk HPV. Conclusion: In Iran there are not many patients with cervical cancer but we have advanced cervical cancers. Also without mass screening program and primary vaccination the researchers worry about increasing of incidence of cervical cancer in younger women. This study showed the similar type of high risk HPV in abnormal pap test and then vaccination plus routine pap test can decrease new cervical cancer in Iran as a developing country. © 2015 Mojgan Karimi-Zarchi et al.