(2015) The serum level of transforming growth factor beta1 and its association with Foxp3 gene polymorphism in Iranian women with recurrent spontaneous abortion. Human Fertility. pp. 54-59.
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Abstract
The aim of the study was to determine the role of transforming growth factor-beta1 (TGF-β1) and Foxp3 (rs3761548) promoter polymorphisms in Iranian women with recurrent spontaneous abortion (RSA). Eighty women with RSA were compared with eighty in a control group. Serum levels of TGF-β1 were measured using ELISA and Foxp3 (rs3761548) promoter polymorphisms using a PCR-RFLP technique. In addition, serum levels of TGF-β1 were compared in different genotypes in the two groups. The women's ages in the two groups were similar (30.15 ± 4.42 years RSA vs. 29.97 ± 4.51 control) as were serum TGF-β1 concentrations in case and control groups (53.42 ± 2.08 ng/ml in control and 56.31 ± 2.58 ng/ml in the RSA group; p = 0.4). Furthermore, there was no significant difference in the genotype frequencies of the rs3761548 Foxp3 gene between the two groups (p = 0.3) and the levels of TGF-β1 were similar in different genotypes. In conclusion, the data indicate that serum TGF-β1 levels and Foxp3 (rs3761548) promoter polymorphism is not a risk factor for RSA and that there is no association between the polymorphism and serum TGF-β1 levels. © 2014 The British Fertility Society.
| Item Type: | Article |
|---|---|
| Keywords: | transcription factor FOXP3; transforming growth factor beta1; biological marker; forkhead transcription factor; FOXP3 protein, human; TGFB1 protein, human; transforming growth factor beta1, adult; Article; controlled study; DNA polymorphism; enzyme linked immunosorbent assay; female; gene frequency; genotype; human; major clinical study; polymerase chain reaction; promoter region; recurrent abortion; restriction fragment length polymorphism; spontaneous abortion; blood; case control study; genetic association; genetics; Iran; metabolism; pregnancy; promoter region; recurrent abortion; single nucleotide polymorphism; young adult, Abortion, Habitual; Adult; Biomarkers; Case-Control Studies; Enzyme-Linked Immunosorbent Assay; Female; Forkhead Transcription Factors; Genetic Association Studies; Humans; Iran; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Pregnancy; Promoter Regions, Genetic; Transforming Growth Factor beta1; Young Adult |
| Page Range: | pp. 54-59 |
| Journal or Publication Title: | Human Fertility |
| Volume: | 18 |
| Number: | 1 |
| Publisher: | Informa Healthcare |
| Depositing User: | ms soheila Bazm |
| URI: | http://eprints.ssu.ac.ir/id/eprint/9354 |
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