Repository of Research and Investigative Information

Repository of Research and Investigative Information

Shahid Sadoughi University of Medical Sciences

Risk factors of breast cancer in the eastern mediterranean region: A systematic review and meta-analysis

(2014) Risk factors of breast cancer in the eastern mediterranean region: A systematic review and meta-analysis. Asian Pacific Journal of Cancer Prevention. pp. 9535-9541.

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Abstract

Background: Identifying risk factors of breast cancer is a key point for preventive strategies to reduce the incidence. The aim of current study was to determine most important risk factors for breast cancer in the Eastern Mediterranean Region (EMR) using a systematic review. Materials and Methods: PubMed, Scopus, Web of Science till August 24, 2012 and the reference lists of all included studies were searched. Analytic studies which had reported odds ratios (OR), relative risk (RR) or required data to calculate them were included. A total of 343 studies were critically appraised and finally 30 studies were meta-analyzed. Heterogeneity between the studies was assessed by I2 and Cochran's Q. Egger's test was used to assess publication bias. Results: Twenty five case-control studies, one nested case-control and four cohort studies were included. The largest ORs were obtained for history of no live birth (2.25; 95CI: 1.58-3.18), body mass index (BMI) more than 30 (2.21; 95CI: 1.71-2.36), age at first pregnancy more than 30 years old (1.52; 95CI: 1.30-1.77) and meat consumption more than three times per week (1.39; 95CI: 1.03-1.87). The other important predictors were higher education and smoking as risk factors, physical activity and ovulatory stimulating medication as protective factors. Conclusions: The most important predictors of breast cancer in EMR were history of no live birth, BMI more than 30, age at first pregnancy more than 30 years old, physical inactivity and smoking. Almost all these risk factors are consistent with known risk factors for this cancer in other parts of the world.

Item Type: Article
Keywords: body mass; Breast Neoplasms; case control study; cohort analysis; female; human; incidence; meta analysis; pregnancy; risk; risk factor; Southern Europe, Body Mass Index; Breast Neoplasms; Case-Control Studies; Cohort Studies; Female; Humans; Incidence; Mediterranean Region; Odds Ratio; Pregnancy; Risk; Risk Factors
Page Range: pp. 9535-9541
Journal or Publication Title: Asian Pacific Journal of Cancer Prevention
Volume: 15
Number: 21
Publisher: Asian Pacific Organization for Cancer Prevention
Depositing User: ms soheila Bazm
URI: http://eprints.ssu.ac.ir/id/eprint/9115

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