Abstract

The main goal was to evaluate the impact of herbal formula TOPALAF powdered herbs including Tribulus terrestris, Orchis mascula, Phoeenix dactylifera, Allium ampeloprasum, Lepidium sativus, Amygdalus communis and Ficus carica on sperm parameters of infertile men and pregnancy outcomes. Sixty-two men were divided into treated (32 men) and control groups (30 men). The treated group was asked to consume packages of herbal medicine TOPALAF and control group took placebo three times a week for three months. The effect of TOPALAF was determined on sperm parameters before and after consumption, then compared to control group. Also the rate of pregnancy was determined in treated group after three months of TOPALAF consumption. There was significant increase in sperm count (42.91±9.29 to 51.05±8.32, P < 0.05) and progressive motility (36.93±3.2 to 52.23±5.7, p<0.001) in treated compared to control group, respectively. There was insignificant difference in sperm normal morphology before and after treatment. The rates of clinical pregnancies were 18.75 and 3.3 in treated and control groups, respectively. It seems TOPALAF would be useful for treatment of male infertility problem if consumed for one spermatogenesis period. However, more studies are required to elucidate probable mechanisms on fertility potential of infertile men. © 2014 AENSI Publisher All rights reserved.