Abstract

Background: Human papilloma virus (HPV) is one of the effective factors in the occurrence and development of cervical and breast cancers. This study aimed to investigate the relationship of lowrisk (6, 11) and high-risk types (16, 18) of papilloma virus and human breast cancer in women. Methods: In this case-control study, the breast tissues of 87 cases of breast cancer and 84 women without malignant diseases (fibrocystic) in Shahid Sadoghi hospital, Yazd city, Iran were selected. To determine the low- and high-risk types of HPV, firstly the nested polymerase chain reaction (PCR) method, and then, the PCR method with specific primers were used. Findings: HPV genome was detected in 22.9 of the samples that 18.3 of cases were containing mucosal genotypes (11, 16, 18 and 6). HPV-16 was the most common genotype in invasive ductal carcinoma. In general, genotype 16 was the most abundant type associated with breast cancer (35) and type 11 had the lowest correlation with breast cancer (5). Conclusion: In this study, the possible association between human papilloma virus infection (especially type 16) and the occurrence and development of breast cancer was confirmed in women of Yazd city. The frequencies of genotypes were not significantly associated with the type of breast cancer tissue.