(2014) Human papilloma virus and nasopharyngeal carcinoma: Pathology, prognosis, recurrence and mortality of the disease. Experimental Oncology. pp. 215-216.
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Abstract
Background: One of the malignant tumors among head and neck cancers is nasopharyngeal carcinoma. Many studies consider human papilloma virus (HPV) as a cause for nasopharyngeal carcinoma. Methods: 41 paraffin-wax-embedded block samples were examined to detect HPV DNA and its subtype's presence by polymerase chain reaction. The recurrence, prognosis and survival were evaluated for an average of 48 months. Results: HPV DNA was positive in 9 patients (22). The overall recurrence rate was 75 in HPV negative patients and 11 in HPV positive ones. The mortality rate in HPV negative and positive patients was 37.5 and 0, respectively. Conclusion: HPV type 18 and 16 were the most common subtypes. Also, it can be implied that patients which are HPV positive had better prognosis and also less recurrence.
| Item Type: | Article |
|---|---|
| Keywords: | cisplatin; fluorouracil; virus DNA, adolescent; adult; aged; Article; cancer combination chemotherapy; cancer mortality; cancer patient; cancer prognosis; cancer radiotherapy; cancer recurrence; cancer survival; cervical lymph node; chemoradiotherapy; clinical article; computer assisted tomography; continuous infusion; DNA isolation; epistaxis; female; follow up; hearing impairment; human; Human papillomavirus type 11; Human papillomavirus type 16; Human papillomavirus type 18; Human papillomavirus type 6; human tissue; male; multimodality cancer therapy; nasopharynx carcinoma; nose obstruction; nuclear magnetic resonance imaging; papillomavirus infection; polymerase chain reaction; recurrence risk; tumor biopsy; Wart virus; cancer staging; Carcinoma, Squamous Cell; genetics; isolation and purification; middle aged; mortality; Nasopharyngeal Neoplasms; Neoplasm Recurrence, Local; Papilloma virus; Papillomavirus Infections; pathology; prognosis; survival rate; very elderly; virology; young adult, Adolescent; Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell; Chemoradiotherapy; DNA, Viral; Female; Follow-Up Studies; Humans; Male; Middle Aged; Nasopharyngeal Neoplasms; Neoplasm Recurrence, Local; Neoplasm Staging; Papillomaviridae; Papillomavirus Infections; Polymerase Chain Reaction; Prognosis; Survival Rate; Young Adult |
| Page Range: | pp. 215-216 |
| Journal or Publication Title: | Experimental Oncology |
| Volume: | 36 |
| Number: | 3 |
| Publisher: | Morion LLC |
| Depositing User: | ms soheila Bazm |
| URI: | http://eprints.ssu.ac.ir/id/eprint/8923 |
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