(2013) Molecular characteristics of bone marrow mesenchymal stem cells, source of regenerative medicine. International Journal of Cardiology. pp. 125-131.
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Abstract
Bone marrow-mesenchymal stem cells (MSCs) are multipotent stem cells capable to differentiate into a variety of lineages. MSCs have emerged as reservoirs for tissue regeneration and wound healing. Through stress signals, MSCs show great tropism for the injured site to manage regenerative process via direct or indirect interactions. MSCs avoid the immune rejection, a high quality factor for treatment of degenerative diseases. Understanding the molecular mechanisms underlying dynamic regulation of various signals, plays an important role for future treatment of heart disorders. © 2011 Elsevier Ireland Ltd.
| Item Type: | Article |
|---|---|
| Keywords: | chemokine receptor CCR2; gamma interferon; gelatinase A; hypoxia inducible factor 1; interleukin 1alpha; interleukin 1beta; STAT protein; tumor necrosis factor alpha; vascular cell adhesion molecule 1; very late activation antigen 4; B7 antigen; CD86 antigen; collagen type 1; collagen type 4; fibroblast growth factor 2; granulocyte colony stimulating factor; interleukin 11; interleukin 6; interleukin 8; Janus kinase; matrix metalloproteinase; mitogen activated protein kinase 1; mitogen activated protein kinase 3; monocyte chemotactic protein 1; osteocalcin; platelet derived growth factor BB; secreted frizzled related protein 2; stem cell factor; stromal cell derived factor 1alpha; toll like receptor 4; transcription factor RUNX2; vasculotropin; Wnt protein, acute heart infarction; antiproliferative activity; cell adhesion; cell aging; cell cycle progression; cell migration; cell polarity; cell proliferation; cell survival; cytokine response; endothelium; gene expression; heart muscle ischemia; human; immunogenicity; mesenchymal stem cell transplantation; microvasculature; phenotype; priority journal; protein expression; protein function; protein phosphorylation; protein protein interaction; regenerative medicine; review; stem cell expansion; T lymphocyte; vascularization; acute heart infarction; bone marrow derived mesenchymal stem cell; calcium signaling; capillary endothelial cell; carditis; cell differentiation; cell function; cell lineage; cell viability; cellular secretion; cellular stress response; cellular stress signal; cytokine release; fibroblast; heart disease; heart infarction prevention; heart muscle cell; heart muscle contractility; hypoxia; immunoregulation; ischemic heart disease; nuclear reprogramming; regenerative medicine; reperfusion injury; Review; sepsis; signal transduction; stem cell mobilization; tissue regeneration, Biochemical Phenomena; Bone Marrow Cells; Humans; Mesenchymal Stem Cell Transplantation; Mesenchymal Stromal Cells; Regenerative Medicine |
| Page Range: | pp. 125-131 |
| Journal or Publication Title: | International Journal of Cardiology |
| Volume: | 163 |
| Number: | 2 |
| Depositing User: | ms soheila Bazm |
| URI: | http://eprints.ssu.ac.ir/id/eprint/8823 |
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