(2013) Management of immune cytopenias in patients with systemic lupus erythematosus - Old and new. Autoimmunity Reviews. pp. 784-791.
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Abstract
There are various immune cytopenias associated with systemic lupus erythematosus (SLE). The most common one is anemia; however, there are different etiologies for the anemia caused by SLE. Anemia could be due to chronic disease, secondary to renal insufficiency, blood loss, drug induced or autoimmune hemolysis. There are other very rare causes of anemia secondary to SLE which include red cell aplasia, aplastic anemia, and microangiopathic hemolytic anemia. Treatment of the anemia would be according to the cause. Leukopenia, neutropenia, and lymphopenia are hematologic complications associated with SLE, and in majority of cases no treatment is required. Thrombocytopenia is one of the complications of SLE and is usually treated by steroids. However, there are significant numbers of patients which will either not respond to or relapse after treatment. This article summarizes immune cytopenias seen in patients with SLE, and it also discusses management of these cytopenias. © 2013 Elsevier B.V.
| Item Type: | Article |
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| Keywords: | alloantibody; autoantibody; azathioprine; corticosteroid; cyanocobalamin; cyclophosphamide; cyclosporin; cyclosporin A; danazol; erythropoietin; fibrinogen receptor; folic acid; glucocorticoid; immunoglobulin; immunomodulating agent; immunosuppressive agent; lactate dehydrogenase; methylprednisolone; mycophenolic acid 2 morpholinoethyl ester; nonsteroid antiinflammatory agent; novel erythropoiesis stimulating protein; phospholipid antibody; prednisolone; prednisone; recombinant erythropoietin; recombinant granulocyte colony stimulating factor; recombinant interleukin 11; rituximab; thrombopoietin receptor; unindexed drug, alopecia; anemia; aplastic anemia; autoimmune disease; autoimmune hemolytic anemia; bleeding; blood transfusion; bone marrow disease; bone marrow suppression; bone marrow toxicity; bone pain; brain pseudotumor; cholestatic hepatitis; chronic disease; cytopenia; disease association; disease exacerbation; drug dose reduction; drug induced disease; drug megadose; gastrointestinal hemorrhage; gastrointestinal symptom; Guillain Barre syndrome; hemolysis; herpes simplex; herpes zoster; human; hyperandrogenism; hypertension; idiopathic thrombocytopenic purpura; immune cytopenia; infection; infection risk; infusion reaction; interstitial pneumonia; kidney dysfunction; kidney failure; leukocytoclastic vasculitis; leukopenia; liver adenoma; lupus erythematosus nephritis; lymphocytopenia; monocytopenia; multiple cycle treatment; myasthenia gravis; nausea; nephrotoxicity; neutropenia; plasmapheresis; premature ovarian failure; pure red cell anemia; rash; review; side effect; splenectomy; systemic lupus erythematosus; thrombocytopenia; thrombocytopenic purpura; thromboembolism; thrombotic thrombocytopenic purpura; treatment response; uric acid blood level; virilization; vomiting; weight gain, Anemia; Humans; Leukopenia; Lupus Erythematosus, Systemic; Lymphopenia; Neutropenia; Pancytopenia; Thrombocytopenia |
| Page Range: | pp. 784-791 |
| Journal or Publication Title: | Autoimmunity Reviews |
| Volume: | 12 |
| Number: | 7 |
| Depositing User: | ms soheila Bazm |
| URI: | http://eprints.ssu.ac.ir/id/eprint/8810 |
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