(2013) 5-Nitro-heteroarylidene analogs of 2-thiazolylimino-4-thiazolidinones as a novel series of antibacterial agents. Medicinal Chemistry Research. pp. 2293-2302.
![[img]](http://eprints.ssu.ac.ir/style/images/fileicons/text.png) |
Text
Med Chem Res 22 (2013) 2293–2302.pdf-aforoumadi-2013-04-10-08-45.pdf Download (1MB) |
Abstract
In the pursuit of novel antibacterial agents with the 2-thiazolylimino-4- thiazolidinone as a core structure, a series of 5-nitro-heteroarylidene and 5-(2-oxoindolin-3-ylidene) analogs of 2-thiazolylimino-5-arylidene-4- thiazolidinone were synthesized and their antibacterial activities were evaluated against some strains of Gram-positive and Gram-negative bacteria, as well as Helicobacter pylori strains. Biological data indicated that 5-nitrofuran analog 5a and 5-nitroimidazole analog 7a containing no substitutions on the thiazole ring were the most potent compounds. © 2012 Springer Science+Business Media, LLC.
| Item Type: | Article |
|---|---|
| Keywords: | 2 (4 (4 methoxyphenyl)thiazol 2 ylimino) 5 ((1 methyl 5 nitro 1h imidazol 2 yl) methylene)thiazolidin 4 one; 2 (4 (4 methoxyphenyl)thiazol 2 ylimino) 5 ((5 nitrofuran 2 yl)methylene)thiazolidin 4 one; 2 (4 (4 methoxyphenyl)thiazol 2 ylimino) 5 ((5 nitrothiophen 2 yl)methylene)thiazolidin 4 one; 2 (4 (4 methoxyphenyl)thiazol 2 ylimino) 5 (2 oxoindolin 3 ylidene)thiazolidin 4 one; 2 (benzodthiazol 2 ylimino) 5 ((1 methyl 5 nitro 1h imidazol 2 yl)methylene)thiazolidin 4 one; 2 (benzodthiazol 2 ylimino) 5 ((5 nitrofuran 2 yl)methylene)thiazolidin 4 one; 2 (benzodthiazol 2 ylimino) 5 ((5 nitrothiophen 2 yl)methylene)thiazolidin 4 one; 2 (benzothiazol 2 ylimino) 5 (2 oxoindolin 3 ylidene)thiazolidin 4 one; 4 nitroimidazole derivative; 5 ((1 methyl 5 nitro 1h imidazol 2 yl)methylene) 2 (4 phenylthiazol 2 ylimino)thiazolidin 4 one; 5 ((1 methyl 5 nitro 1h imidazol 2 yl)methylene) 2 (thiazol 2 ylimino)thiazolidin 4 one; 5 ((5 nitrofuran 2 yl)methylene) 2 (4 phenylthiazol 2 ylimino)thiazolidin 4 one; 5 ((5 nitrofuran 2 yl)methylene) 2 (thiazol 2 ylimino)thiazolidin 4 one; 5 ((5 nitrothiophen 2 yl)methylene) 2 (4 phenylthiazol 2 ylimino)thiazolidin 4 one; 5 ((5 nitrothiophen 2 yl)methylene) 2 (thiazol 2 ylimino)thiazolidin 4 one; 5 (2 oxoindolin 3 ylidene) 2 (4 phenylthiazol 2 ylimino)thiazolidin 4 one; 5 (2 oxoindolin 3 ylidene) 2 (thiazol 2 ylimino)thiazolidin 4 one; antiinfective agent; nitrofuran derivative; unclassified drug, antibacterial activity; article; bacterial strain; drug synthesis; Gram negative bacterium; Gram positive bacterium; Helicobacter pylori; minimum inhibitory concentration; nonhuman |
| Page Range: | pp. 2293-2302 |
| Journal or Publication Title: | Medicinal Chemistry Research |
| Volume: | 22 |
| Number: | 5 |
| Depositing User: | ms soheila Bazm |
| URI: | http://eprints.ssu.ac.ir/id/eprint/8734 |
Actions (login required)
 |
View Item |