(2022) A Post-Marketing Surveillance Study to Evaluate the Safety Profile of AlvotereⓇ (Docetaxel) in Iranian Patients Diagnosed with Different Types of Cancers Receiving Chemotherapy. Current Therapeutic Research - Clinical and Experimental. ISSN 0011393X (ISSN)
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Abstract
Background: Docetaxel is a clinically well established antimitotic chemotherapy medication. Labeled docetaxel indications are breast cancer, gastric cancer, head and neck cancer, non–small cell lung cancer, and prostate cancer. Objective: This is a Phase IV study to evaluate the safety profile of docetaxel (Alvotere; NanoAlvand, Iran) in Iranian patients diagnosed with different types of cancers receiving chemotherapy regimens with docetaxel. Methods: Patients who received Alvotere as a part of their chemotherapy regimen were enrolled in this Phase IV, observational, multicenter, open-label study. Alvotere was administrated as a single agent or in combination with other chemotherapy agents. Safety parameters in each cycle were assessed, and the related data were recorded in booklets. Findings: A total of 411 patients with different types of cancers were enrolled from 25 centers in Iran. The most common malignancies among participants were breast cancer (49.88), followed by gastric cancer (22.63). Participants’ mean age was 53.33 years, and the mean total dose used in each cycle was 132 mg. According to the results, 341 patients experienced at least 1 adverse event, that the most common was alopecia (41.12). In total, 92 (22.38) patients had at least 1 adverse event of grade 3 or 4, and 25 (6.08) patients showed 54 serious adverse events, which the causality assessment for all was possibly related to Alvotere. There was a significant difference between men and women in the incidence of skin and subcutaneous tissue disorders (55.63 in women vs 41.73 in men; P = 0.009). Also, the incidence of gastrointestinal disorders, nervous system disorders, skin and subcutaneous tissue disorders, hepatic enzymes increase, and fluid retention was significantly higher (P < 0.05) in patients receiving anthracyclines in their chemotherapy regimens. Conclusions: The findings of this open-label, observational, multicenter, postmarketing surveillance showed that Alvotere appears to have an acceptable safety profile in Iranian cancer patients receiving chemotherapeutic regimens. (Curr Ther Res Clin Exp. 2022; 82:XXX–XXX) © 2022 Elsevier HS Journals, Inc. © 2021
| Item Type: | Article |
|---|---|
| Keywords: | Alvotere cancer observational Phase IV safety alanine aminotransferase anthracycline aspartate aminotransferase docetaxel adult adverse event alopecia Article asthenia breast cancer cancer chemotherapy cancer combination chemotherapy cancer patient clinical trial Common Terminology Criteria for Adverse Events controlled study drug safety female fluid retention gastrointestinal disease head and neck cancer human incidence informed consent Iran Iranian people leukopenia major clinical study male middle aged multicenter study neurologic disease non small cell lung cancer observational study phase 4 clinical trial postmarketing surveillance professional standard prostate cancer sample size skin disease stomach cancer |
| Journal or Publication Title: | Current Therapeutic Research - Clinical and Experimental |
| Journal Index: | Scopus |
| Volume: | 96 |
| Identification Number: | https://doi.org/10.1016/j.curtheres.2021.100659 |
| ISSN: | 0011393X (ISSN) |
| Depositing User: | ms soheila Bazm |
| URI: | http://eprints.ssu.ac.ir/id/eprint/34441 |
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