(2022) Investigating the Therapeutic Effect of β-Interferon and Methylprednisolone on COVID-19 Patients’ Consequence: A Non-Randomized, Double-Blinded, Controlled Study. Journal of Advances in Medical and Biomedical Research. pp. 486-492. ISSN 26766264 (ISSN)
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Abstract
Background & Objective: Due to the severe inflammatory conditions and cytokine storm in COVID-19 disease, corticosteroids are used worldwide as adjunctive therapy for these patients due to their anti-inflammatory effects. However, due to limited and inconsistent information about the effectiveness of this drug, this study aimed to investigate the benefit of combined use of β-interferon and methylprednisolone in patients with COVID-19. Materials & Methods: 57 patients infected with SARS coronavirus 2 underwent treatment. Laboratory parameters, hospitalization duration, and clinical outcomes in these patients were studied. Results: Statistical analysis showed no correlation between combination therapy with the hospitalization duration (P=0.22) and mortality (P=0.48). Also, the findings of this study showed that the ESR level in patients receiving combination therapy with methylprednisolone and interferon beta decreased significantly at the end of the intervention (P=0.0001). At the end of the study, the levels of neutrophils (P=0.001) and lymphocytes (P-value=0.0001) in the blood in the interferon group showed a significant change. Conclusion: This study showed no effect of adding methylprednisolone and interferon beta to the treatment protocol on mortality in the patients. © 2022, Zanjan University of Medical Sciences and Health Services. All rights reserved.
| Item Type: | Article |
|---|---|
| Keywords: | COVID-19 Interferon-beta Methylprednisolone SARS-CoV-2 beta interferon C reactive protein corticosteroid hemoglobin hydroxychloroquine lopinavir plus ritonavir naproxen adult aged antiinflammatory activity Article breathing rate cardiovascular disease clinical outcome clinical trial computer assisted tomography controlled study coronavirus disease 2019 cytokine storm diabetes mellitus double blind procedure drug efficacy drug safety erythrocyte sedimentation rate evening dosage female heart rate hospitalization human human cell hypertension hypoxia imaging inflammation laboratory test length of stay leukocyte lung disease lung infiltrate lymphocyte lymphocytopenia major clinical study male morning dosage mortality neutrophil outcome assessment oxygen saturation oxygen therapy polymerase chain reaction reverse transcription polymerase chain reaction Severe acute respiratory syndrome coronavirus 2 therapy effect thorax radiography throat swab |
| Page Range: | pp. 486-492 |
| Journal or Publication Title: | Journal of Advances in Medical and Biomedical Research |
| Journal Index: | Scopus |
| Volume: | 30 |
| Number: | 143 |
| Identification Number: | https://doi.org/10.30699/jambs.30.143.486 |
| ISSN: | 26766264 (ISSN) |
| Depositing User: | ms soheila Bazm |
| URI: | http://eprints.ssu.ac.ir/id/eprint/34399 |
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