(2024) A Comprehensive Compilation of Data on the Relationship Between Surfactant Protein-B (SFTPB) Polymorphisms and Susceptibility to Neonatal Respiratory Distress Syndrome. Fetal and Pediatric Pathology. pp. 399-418. ISSN 15513815 (ISSN)
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Abstract
Background: This study aims to explore the association between variations in the Surfactant Protein-B (SFTPB) gene and the risk of neonatal respiratory distress syndrome (NRDS). Methods: A comprehensive literature search was conducted across PubMed, Scopus, EMBASE, and CNKI databases up to February 10, 2024, to identify pertinent studies. Results: A total of seventeen studies examining the +1580 C/T polymorphism (2,058 cases and 2,596 controls) and five studies investigating the −18 A/C polymorphism (680 cases and 739 controls) were included in the analysis. The pooled data indicated that the +1580 C/T polymorphism confers a protective effect against NRDS in various populations and ethnic groups. Conversely, the −18 A/C polymorphism did not demonstrate a significant association either globally or among Asian neonates. Conclusions: The +1580 C/T variant appears to be protective against NRDS, whereas the −18 A/C polymorphism shows minimal impact on the disease’s progression. © 2024 Taylor & Francis Group, LLC.
| Item Type: | Article |
|---|---|
| Keywords: | infants polymorphism premature infants respiratory distress syndrome SFTPB Genetic Predisposition to Disease Humans Infant, Newborn Polymorphism, Single Nucleotide Pulmonary Surfactant-Associated Protein B Respiratory Distress Syndrome, Newborn surfactant protein B Asian drug therapy ethnic group female human infant major clinical study neonatal respiratory distress syndrome newborn prematurity review genetic predisposition genetics meta analysis single nucleotide polymorphism |
| Page Range: | pp. 399-418 |
| Journal or Publication Title: | Fetal and Pediatric Pathology |
| Journal Index: | Scopus |
| Volume: | 43 |
| Number: | 5 |
| Identification Number: | https://doi.org/10.1080/15513815.2024.2390932 |
| ISSN: | 15513815 (ISSN) |
| Depositing User: | ms soheila Bazm |
| URI: | http://eprints.ssu.ac.ir/id/eprint/34312 |
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