Abstract

Objectives: The link between the bone morphogenetic protein 14 (BMP14) +104T/C polymorphism and total knee arthroplasty (TKA) susceptibility has been previously studied with inconclusive findings. This research seeks to assess the association of the BMP14 +104T/C polymorphism with TKA predisposition. Methods: A comprehensive search of databases such as PubMed, ResearchGate, Scopus, and CNKI was conducted up to September 01, 2023. Results: Eight original studies involving 4,484 cases and 5,391 controls were reviewed. The findings indicate a protective effect of the BMP14 +104T/C variant against TKA susceptibility across all five genetic models: allele model (T vs. C: OR 0.856, 95 CI 0.805-0.911, p≤0.001, A), homozygote model (TT vs. CC: OR = 0.748, 95 CI 0.656-0.853, p≤0.001), dominant model (TT+TC vs. CC: OR = 0.855, 95 CI 0.705-0.975, p=0.020), and recessive model (TT vs. TC+CC: OR = 0.797, 95 CI 0.705-0.902, p≤0.001). Stratified analyses considering factors such as ethnicity, control source, country, and genotyping methods consistently revealed significant associations. Conclusion: This finding suggests that individuals carrying the C allele of the BMP14 +104T/C polymorphism may have a lower chance of requiring TKA. These findings provide insights into the genetic factors that may influence the need for TKA and underscore the importance of further investigation in this area. © 2024 by Eurasian Journal of Medicine and Oncology.