Abstract

The current study was aimed to evaluate effect of bell pepper alcoholic extract ointment in wound healing of male wistar rats. Twenty for male Wistar rats were randomly divided into four experimental groups. Experimental wound was induced on the anterior dorsal side of each Wistar rat. Group A served as control and received basal formulation ointment. Groups B, C and D received 2 and 4 and 6 percentage of bell pepper alcoholic extract. Wound healing activity as a closure percentage was determined on days five, 15 and 25 post operations. The number of fibroblast and macrophages, collagen deposition and neovascularization were assessed on 4, 8, 15 and 25 days after wound incision. Data showed that the wound area significantly decreased in bell pepper alcoholic extract treated groups compared to control group on days five, 15 and 25 post operations, respectively (P <= 0.05). Application of bell pepper alcoholic extract, increased fibroblast and macrophages distribution and up regulated the new vessels formation and collagen deposition on days 4, 8, 15 and 25 and 30 after wound induction significantly (P <= 0.05). In conclusion we suggested that the bell pepper alcoholic extract application at 2, 4, and 6 percentages was useful for wound healing in male Wistar rats.