Abstract

Background: Non alcoholic fatty liver disease(NAFLD) has a very high prevalence. Some studies have shown that diets high in sugars have etiologic role. In this study the effects of different sugars on histology of rat's liver studied. Methods: Male Ratus Morvegicus Dvivius rats (n=40) weighing 250-270 gram were obtained from the animal house of shahid sadoughi university of medical science. Lactose, sucrose and fructoses were supplied as 10 drinking solutions. When the rats were 25 overweight, the animals were sacrificed and their liver was extracted and histologically was evaluated. Results: No evidence of macro or microvesicular steatosis were found in liver specimens of control and tests groups.According to PV=1,there was no meaningful difference regarding histological findings in tests and control groups. Conclusion: To explain these subjects we should say that 1-NAFLD is a multifactorial disorder and only added sugar is inadequate in development of this disease. 2-More complex diet is needed.3- Longer term exposure to sugars is necessary and 4- Genetic factor is important. Since neither control nor test groups show fatty liver, it is possible that our rats were not genetically susceptible to fatty liver. There is no objective ground to support that moderate intake of sugars is unsafe. © IDOSI Publications, 2013.