Abstract

Introduction: Ovarian cancer is the fifth cause of cancer death among women. P53 gene and Ki67 can play a significant role in the progression of tumors. This study was conducted to review the frequency of P53 and Ki67 markers in different types of ovarian epithelial tumors and their relationship with the prognosis of the disease. Materials and Methods: This descriptive analytical study was done on all paraffin-embedded blocks of patients with ovarian surface epithelial tumors (malignant, benign, and borderline) referred to pathology ward of Shahid Sadoughi educational General Hospital from 2013 to 2017 by using the census method. Ki67 and P53 immunohistochemical tests were then performed on all the samples. Data such as (age, pathology report, survival status, affected side, size of tumor) were extracted from the hospital folders. Data were analyzed in SPSS version 22. P < 0.05 was set as the level of statistical significance. Results: A total of 86 cases, including 40 serous and mucinous carcinomas, 36 serous and mucinous cystadenomas, and ten serous and mucinous borderline tumors, were examined. The mean age of the patients was 44.29 ± 16.91 years, and their age range was 15–79. A significant relationship was found between the type of tumor and the frequency of P53 and Ki67 (P < 0.05). Nonetheless, no significant relationships were observed between tumor grade and these two markers. Ki67 staining susceptibility was significantly higher in the undifferentiated tumors than in the others (P < 0001). The mean survival was 40.67 months, and a significant relationship was observed between age and survival (P < 0.002) and age and the frequency of P53 and Ki67 and tumor type (P < 0.05). Discussion and Conclusion: The results of this study showed that both P53 and Ki67 are predictors of overall survival, tumor type, disease grade, and disease prognosis in patients with different ovarian epithelial tumors and can be used in them alongside biopsy. © 2018, Association of Gynecologic Oncologists of India.