(2019) Curcumin exerts beneficial role on insulin resistance through modulation of SOCS3 and Rac-1 pathways in type 2 diabetic rats. Journal of Functional Foods. ISSN 17564646 (ISSN)
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Abstract
The present study examined the anti-diabetic effect of curcumin (cur) on insulin resistance (IR) through modulation of SOCS3 and Rac-1 pathways in rats with type 2 diabetes (T2D) induced by high-fat diet (HFD) and streptozotocin (STZ). The expression pattern of proteins and genes associated with insulin signaling pathways was measured by western blot and real-time PCR. Moreover, biomarkers of the oxidative stress in skeletal muscles were measured. Diabetic rats showed increased malondialdehyde (MDA) in skeletal muscles with a concomitant decrease in superoxide dismutase (SOD), and catalase (CAT) activities. Moreover, diabetic rats showed heightened levels of SOCS-3 and STAT-3 expression, as well as decreased IRS-1, Rac1, and Rac-GTP in skeletal muscles. The level of antioxidant enzyme activities reached the baseline after the treatment with cur. The anti-diabetic effect of cur was exerted by a reduction in the expression of STAT-3, SOCS3, as well as the elevation in IRS-1, Rac1, and Rac-GTP. © 2019 Elsevier Ltd
| Item Type: | Article |
|---|---|
| Keywords: | Curcumin IRS1 SOCS3 STAT3 Type 2 diabetes mellitus |
| Journal or Publication Title: | Journal of Functional Foods |
| Volume: | 60 |
| Identification Number: | https://doi.org/10.1016/j.jff.2019.103430 |
| ISSN: | 17564646 (ISSN) |
| Depositing User: | Mr mahdi sharifi |
| URI: | http://eprints.ssu.ac.ir/id/eprint/31913 |
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