Abstract

The aim of this study is Comparison of pregnancy outcomes in high risk pregnant women with normal FBS after OGTT test in first trimester of pregnancy and 24-28 weeks of pregnancy. This was a follow up study on pregnant mothers who were at risk of developing gestational diabetes at the beginning of the first trimester of pregnancy. Patients were divided to 2 groups: 164 women had a 2-hour OGTT test with 75 g glucose in the first trimester and 251 ones had-hour OGTT test with 75 g glucose in the second trimester. The studied populations were monitored during the entire pregnancy period in term of complications of gestational diabetes. All of this information was recorded and analyzed by SPSS 19. Based on results, there is no significant difference between two groups in term of these risk factors. The frequency of gestational diabetes mellitus in the first trimester was significantly more than the second trimester (p value = 0.001). In the population with GDM, there was no significant difference between maternal and fetal complications in the two groups. The prevalence of preeclampsia, macrosomia, cesarean section related to gestational diabetes, fetal complications were not significant between two groups. There was a significant difference between the two groups in terms rate of insulin therapy (p-value = 0.035), but there was no significant difference between the two groups in term of other pharmacological and non-pharmacological treatment. Due to the lack of significant difference in some of the complications of gestational diabetes (preeclampsia, cesarean section associated with GDM) and fetal complications between the two groups, it can be concluded that early screening before 24 weeks in women with risk factors for gestational diabetes leads to more costs and discomfort for pregnant mothers without any So, screening for each patient should be done individually in accordance with an accurate assessment of his pregnancy and risk factors for diabetes. © 2020 Journal of Advanced Pharmacy Education & Research.