Abstract

BACKGROUND: The promoter -1082 A/G (rs1800896) polymorphism of Interleukin-10 (IL-10) gene have been widely reported and considered to have a significant role on gastric cancer risk, but the results are inconsistent. OBJECTIVE: To clarify the association, we conducted a meta-analysis to investigate the associations IL-10 -1082 A/G polymorphism with gastric cancer. METHODS: Eligible articles were identified by searching databases including PubMed, Web of Science, and Google Scholar up to August 03, 2017. Odds ratios (OR) with corresponding 95 confidence intervals (CIs) were used to assess the association. RESULTS: A total of 30 case-control studies with 6,101 cases and 8,557 controls were included in this meta-analysis. Overall, a significant association between IL-10 -1082 A/G polymorphism and gastric cancer risk was observed under the allele model (G vs A: OR=1.305, 95 CI=1.076-1.584; P=0.007), heterozygote model and (GA vs AA: OR=1.252, 95 CI=1.252-1.054; P=0.011) and dominant model (GG+GA vs AA: OR=1.264, 95 CI=1.053-1.516; P=0.012). In the subgroup analysis by ethnicity, increased gastric cancer risk were found in Asians under the allele model (G vs A: OR=1.520, 95 CI=1.172-1.973; P=0.002), homozygote model (GG+GA vs AA: OR=1.571, 95 CI=1.023-2.414; P= 0.039), heterozygote model (GA vs AA: OR=1.465, 95 CI=1.192-1.801; P</=0.001) and dominant model (GG+GA vs AA: OR=1.448, 95 CI=1.152-1.821; P=0.002), but not among Caucasian and Latinos populations. CONCLUSION: These results suggested that the IL-10 -1082 A/G (rs1800896) polymorphism might contribute to the gastric cancer susceptibility, especially among Asians.