(2018) Association of GDF-5 rs143383 polymorphism with radiographic defined knee osteoarthritis: A systematic review and meta-analysis. Journal of Orthopaedics. pp. 945-951. ISSN 0972-978X (Print) 0972-978X (Electronic) 0972-978X (Linking)
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Abstract
OBJECTIVE: To assess the association of GDF-5 rs143383 polymorphism with radiographic defined knee osteoarthritis (OA), a systematic review and meta-analysis was conducted. METHODS: A total of 17 relevant case-control studies with 7424 cases and 11,310 controls was collected from several electronic databases up to June 2018. RESULTS: The pooled results showed that GDF-5 rs143383 polymorphism was significantly associated with radiographic defined knee OA in overall and stratified analysis by ethnicity, source of controls and genotyping techniques. CONCLUSIONS: The GDF-5 rs143383 polymorphism might be used as a relevant risk estimate for radiographic defined Knee OA.
| Item Type: | Article |
|---|---|
| Keywords: | GDF-5 gene Knee Meta-analysis Osteoarthritis Radiographic |
| Page Range: | pp. 945-951 |
| Journal or Publication Title: | Journal of Orthopaedics |
| Volume: | 15 |
| Number: | 4 |
| Identification Number: | https://doi.org/10.1016/j.jor.2018.08.033 |
| ISSN: | 0972-978X (Print) 0972-978X (Electronic) 0972-978X (Linking) |
| Depositing User: | Mr mahdi sharifi |
| URI: | http://eprints.ssu.ac.ir/id/eprint/31184 |
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