(2021) Association of Endothelial Nitric Oxide Synthase 894G > T Polymorphism with Preeclampsia Risk: A Systematic Review and Meta-Analysis based on 35 Studies. Fetal and Pediatric Pathology. pp. 455-470. ISSN 1551-3823 (Electronic) 1551-3815 (Linking)
Full text not available from this repository.
Abstract
Several case-control studies have been performed to investigate the association between 894 G > T polymorphism in endothelial nitric oxide synthase (eNOS) gene and susceptibility to preeclampsia. However, the results were inconsistent and inconclusive. Therefore, we conducted this meta-analysis to investigate the association. Methods: All studies published up to September 30, 2019 were identified by searching electronic databases such as PubMed, EMBASE, CNKI, and WANFANG. Results: A total of 35 case- control studies with 4,254 cases and 5,801 controls were selected. There was a significant association between the eNOS 894 G > T and preeclampsia risk. When stratified by ethnicity, an increased risk of preeclampsia was found in Caucasian and Mixed populations, but not in Asians or Africans. Conclusion: Based on our meta-analysis, the eNOS 894 G > T polymorphism was associated with an increased risk of preeclampsia, especially among Caucasian and Mixed populations.
| Item Type: | Article |
|---|---|
| Keywords: | Case-Control Studies Female Genetic Predisposition to Disease Humans *Nitric Oxide Synthase Type III/genetics Polymorphism, Genetic Polymorphism, Single Nucleotide *Pre-Eclampsia/genetics Pregnancy Preeclampsia eNOS gene meta-analysis polymorphism |
| Page Range: | pp. 455-470 |
| Journal or Publication Title: | Fetal and Pediatric Pathology |
| Volume: | 40 |
| Number: | 5 |
| Identification Number: | https://doi.org/10.1080/15513815.2019.1710880 |
| ISSN: | 1551-3823 (Electronic) 1551-3815 (Linking) |
| Depositing User: | Mr mahdi sharifi |
| URI: | http://eprints.ssu.ac.ir/id/eprint/31070 |
Actions (login required)
 |
View Item |