(2021) Association between interleukin-32 gene polymorphism and susceptibility to preeclampsia. Hypertension in Pregnancy. pp. 218-225. ISSN 1525-6065 (Electronic) 1064-1955 (Linking)
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Abstract
OBJECTIVE: To determine association between IL-32 gene polymorphism, and serum levels of IL-32 and susceptibility to preeclampsia (PE). METHODS: The frequency of IL-32 rs9927163 and rs4786370 polymorphisms was determined by PCR-RFLP. Also ELISA was used to determine the levels of serum IL-32. RESULTS: Regarding rs4786370 C/T SNPs, the frequencies of CT, TT genotypes, and T allele were shown to be higher in the PE patients. IL-32 serum level significantly increased in the PE patients. CONCLUSION: Variety of allele and genotype IL32 rs4786370 as well as a rise in serum level of IL-32 can be regarded as a risk factor for PE.
| Item Type: | Article |
|---|---|
| Keywords: | Adult Alleles Case-Control Studies Enzyme-Linked Immunosorbent Assay Female Gene Frequency Genetic Predisposition to Disease Genotype Humans Interleukins/*blood/*genetics Polymorphism, Single Nucleotide Pre-Eclampsia/*blood/genetics Pregnancy Gene polymorphism il-32 preeclampsia |
| Page Range: | pp. 218-225 |
| Journal or Publication Title: | Hypertension in Pregnancy |
| Volume: | 40 |
| Number: | 3 |
| Identification Number: | https://doi.org/10.1080/10641955.2021.1958836 |
| ISSN: | 1525-6065 (Electronic) 1064-1955 (Linking) |
| Depositing User: | Mr mahdi sharifi |
| URI: | http://eprints.ssu.ac.ir/id/eprint/30946 |
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