(2021) A meta-analysis for association of TNF-alpha -308G>A polymorphism with susceptibility to Ankylosing Spondylitis. Journal of Orthopaedics. pp. 79-87. ISSN 0972-978X (Print) 0972-978X (Electronic) 0972-978X (Linking)
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Abstract
OBJECTIVE: We performed a meta-analysis of all eligible studies on the association of TNF-alpha -308G>A polymorphism with risk of Ankylosing spondylitis (AS). METHODS: A comprehensive literature research was performed in online databases. RESULTS: A total of 28 studies with 4489 cases and 5919 controls were included. Pooled ORs showed a significant association between TNF-alpha -308G>A polymorphism and risk of AS. Moreover, stratified analysis by ethnicity showed a significant association between TNF-alpha -308G>A polymorphism and AS risk in Asians, Caucasians and Mixed populations, but not in Chinese population. CONCLUSION: This meta-analysis suggested that the TNF-alpha -308G>A polymorphism was associated with AS risk.
| Item Type: | Article |
|---|---|
| Keywords: | Ankylosing spondylitis Ethnicity Joints inflammation Meta-analysis Polymorphism TNF-alpha |
| Page Range: | pp. 79-87 |
| Journal or Publication Title: | Journal of Orthopaedics |
| Volume: | 26 |
| Identification Number: | https://doi.org/10.1016/j.jor.2021.07.015 |
| ISSN: | 0972-978X (Print) 0972-978X (Electronic) 0972-978X (Linking) |
| Depositing User: | Mr mahdi sharifi |
| URI: | http://eprints.ssu.ac.ir/id/eprint/30945 |
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