Repository of Research and Investigative Information

Repository of Research and Investigative Information

Shahid Sadoughi University of Medical Sciences

Acetylcholinesterase inhibitory activity of Ferula plants and their potential for treatment of Alzheimer's disease

(2023) Acetylcholinesterase inhibitory activity of Ferula plants and their potential for treatment of Alzheimer's disease. Journal of complementary & integrative medicine. ISSN 1553-3840 (Electronic) 1553-3840 (Linking)

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Official URL: https://www.ncbi.nlm.nih.gov/pubmed/36857494

Abstract

One of the current strategies in the treatment of Alzheimer's disease is using drugs with acetylcholinesterase (AChE) inhibitory property. The existence of various compounds in plants as a potential source for finding new compounds to treat Alzheimer's disease is a scientific fact. Many secondary metabolites and plant extracts have been reported with the ability to inhibit the AChE activity and improve memory and learning. These compounds can increase the concentration of acetylcholine in the brain and improve cholinergic function in individuals with Alzheimer's disease and reduce the symptoms of this neurological disorder. Plants of Ferula genus are a good source of biologically active compounds such as sesquiterpene derivatives, coumarin derivatives and sulfur-containing compounds. Numerous studies on various extracts or purified compounds of Ferula genus have shown that members of this genus have the inhibitory properties on acetylcholinesterase and can also be effective in improving Alzheimer's and amnesia. This review article summarizes studies on plants of Ferula extracts and their derived compounds to find AChE inhibitors.

Item Type: Article
Keywords: Alzheimer's disease Ferula acetylcholinesterase inhibitors
Journal or Publication Title: Journal of complementary & integrative medicine
Identification Number: https://doi.org/10.1515/jcim-2022-0284
ISSN: 1553-3840 (Electronic) 1553-3840 (Linking)
Depositing User: Mr mahdi sharifi
URI: http://eprints.ssu.ac.ir/id/eprint/30838

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