(2017) Facile synthesis and antiproliferative activity of 7H-benzo 7,8 chromeno 2,3-<i>d</i> pyrimidin-8-amines. European Journal of Medicinal Chemistry. pp. 128-136. ISSN 0223-5234
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Abstract
A series of 7H-benzo7,8chromeno2,3-dpyrimidin-8-amines 6a-t were synthesized as new potential antiproliferative agents. The in vitro antiproliferative activity evaluation of title compounds using MU assay revealed that most compounds showed significant activity against tested cancer cell lines (A549, MOLT-4, and HeLa). The 2-fluoro-aniline derivatives 6e and 61 were the most active compounds against A549 and MOLT-4 cells, respectively. The benzylamine analog 6h showed superior activity against HeLa cells. However, compound 61 with IC50 values of 5.2-6.9 mu M had the best profile of activity against all tested cell lines. The morphological and flow cytometric analyses showed that compound 61 can induce apoptosis in the MOLT-4 cells. (C) 2016 Elsevier Masson SAS. All rights reserved.
| Item Type: | Article |
|---|---|
| Keywords: | Anticancer Cytotoxic agents Benzochromene Polycyclic compounds anticancer agents biological evaluation proliferation chemotherapy derivatives resistance discovery delivery analogs assay Pharmacology & Pharmacy |
| Page Range: | pp. 128-136 |
| Journal or Publication Title: | European Journal of Medicinal Chemistry |
| Journal Index: | WoS |
| Volume: | 127 |
| Identification Number: | https://doi.org/10.1016/j.ejmech.2016.12.037 |
| ISSN: | 0223-5234 |
| Depositing User: | Mr mahdi sharifi |
| URI: | http://eprints.ssu.ac.ir/id/eprint/30573 |
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