(2015) SYNTHESIS AND EVALUATION OF COUMARIN- RESVERATROL HYBRIDS AS 15-LIPDXYGENAZE INHIBITORS. Synthetic Communications. pp. 751-759. ISSN 0039-7911
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Abstract
A series of coumarin-resveratrol hybrids, 3-arylcoumarin derivatives 3a-u, were synthesized through the intermolecular condensation reaction of various salicylaldehydes and phenylacetic acids in the presence of 1,4-diazabicyclo2.2.2octane under solvent-free conditions. All the synthesized compounds were screened for their inhibitory potency against soybean 15-lipoxygenase. Among them, three compounds (3c, 3j, and 3q) showed good enzyme-inhibitory activities.
| Item Type: | Article |
|---|---|
| Keywords: | 3-Arylcoumarins DABCO salicylaldehyde solvent-free soybean 15-lipoxygenase efficient synthesis monoamine-oxidase derivatives potent series 15-lipoxygenase condensation antioxidant oxidation complex Chemistry |
| Page Range: | pp. 751-759 |
| Journal or Publication Title: | Synthetic Communications |
| Journal Index: | WoS |
| Volume: | 45 |
| Number: | 6 |
| Identification Number: | https://doi.org/10.1080/00397911.2014.979947 |
| ISSN: | 0039-7911 |
| Depositing User: | Mr mahdi sharifi |
| URI: | http://eprints.ssu.ac.ir/id/eprint/30455 |
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